STUDIES ON TETRAHYDROISOQUINOLINES (THI) (I) BRONGHODILATOR ACTIVITY AND STRUCTURE-ACTIVITY RELATIONSHIP

Anti-Mycobacterium avium activity of quinolones: structure-activity relationship studies.

The structures and inhibitory activities of 88 quinolones, previously studied as potential in vitro inhibitors of 14 selected strains of Mycobacterium avium complex, were examined in an effort to identify a quinolone with optimal activity towards all strains. A MULTICASE structure-activity relationship analysis of the inhibitory activities of these 88 quinolones against 14 strains of M. avium w...

quantitative structure activity relationship and docking studies on imidazole derivatives as p-glycoprotein inhibitors

Quantitative structure--activity relationship (QSAR) studies of mutagens and carcinogens.

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Synthesis and structure–activity relationship studies of teixobactin analogues

A new series of teixobactin analogues were synthesized via an oxidative cyclative cleavage approach using aryl hydrazide resin as the solid support. Structure–activity relationship studies revealed that the guanidine or amine group at position 10, the hydroxyl group of Ser7 residue and the NH proton of the N-terminal Phe1 residue are critical to the antibacterial activities, while side chain si...

Quantitative Structure-Activity Relationship Studies of 4-Imidazolyl- 1,4-dihydropyridines as Calcium Channel Blockers

Objective(s): The structure- activity relationship of a series of 36 molecules, showing L-type calcium channel blocking was studied using a QSAR (quantitative structure–activity relationship) method. Materials and Methods: Structures were optimized by the semi-empirical AM1 quantum-chemical method which was also used to find structure-calcium channel blocking activity trends. Several types of ...